Tissue Reaction to Polyglycolic Acid Suture Compared to Monofilament Nylon

Abstract

Comparative study on tissue reaction to Polyglycolic Acid (Dexon), Nylon and Dacrofil suture materials on incised skin wounds was carried out on three healthy East African short horned goats. The tissue reaction was studied by gross examination and biopsy specimen for histology. The initial tissue reaction in all wounds was basically similar. After two weeks, tissue reaction to Nylon and Dacrofil had subsided when compared to that of Dexon. Some cellular infiltration persisted in the wounds sutured with Dexon particularly neutrophil and macrophages. However, there was substantial fibroblast proliferation, collagen fiber formation and epithelialization which were similar to those of Nylon and Dacrofil. This indicates that Dexon is primarily responsible for the absorption of suture materials and interfered minimally with wound healing process. It is therefore suggested that Dexon can be used as skin suture material in goats without complications