Antibiotics resistance in Sub Saharan Africa; literature review from 2010 – 2017

Abstract

Antibiotics saves millions of lives in human and animal from bacterial infections, but resistance has been occurred and spreading borderless which pose health and economic problems. This study aimed to describe epidemiology (prevalence) of antibiotic resistant bacteria in human and animals and describing risk factors with strategic control efforts in Sub-Sahara Africa countries. Total 72 articles published from 2010 to 2017 were reviewed which reported on bacterium resistance to commonly-used antibiotics of different groups. Majority of isolated bacteria were highly resistant to b-lactams, Tetracycline and Sulphonamide, moderate resistant to Gentamycine and Aminoglycoside with low resistant to cephalosporin and quinolones for bacteria isolated from human while isolates from animal have high resistance to majority of antibiotic. High antibiotic resistant was associated by presence of weak/no regulation and irrational antibiotics use in Animal and Human health system, despite there is paucity of published data from central and southern African countries, lack of data sharing among laboratories and presence of few initiatives on control strategies of antimicrobial resistance while most of them are faced by resource limitations (skilled personnel, Equipments and Fund allocation). This study recommend that awareness on rational antibiotic use must be created, strong regulation to limit accessibility of antibiotics over the counter prescription, strengthening laboratory based diagnosis and surveillance, Infection control and prevention in hospitals with strong biosafety and biosecurity in animal farms are crucial. Adoption of “One Health Approach” is very important through multisectoral involvement, information sharing and networking